RT Journal Article
T1 Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling
A1 Moreno, Estefanía
A1 Andradas, Clara
A1 Medrano, Mireia
A1 Caffarel, María M.
A1 Blasco-Benito, Sandra
A1 Pazos, M. Ruth
A1 Irving, Andrew J.
A1 Lluís, Carme
A1 Canela, Enric I.
A1 McCormick, Peter J.
A1 Gómez Cañas, María
A1 Pérez Gómez, Eduardo
A1 Fernández Ruiz, José Javier
A1 Guzmán Pastor, Manuel
A1 Sánchez García, María Cristina
AB The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.
PB Elsevier
SN 0021-9258
YR 2014
FD 2014-08
LK https://hdl.handle.net/20.500.14352/93416
UL https://hdl.handle.net/20.500.14352/93416
LA eng
NO Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI,Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C. Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling. J Biol Chem. 2014, 289(32):21960-72.
DS Docta Complutense
RD 17 abr 2025