RT Journal Article
T1 Corneal densitometry and biomechanical properties in patients with primary congenital glaucoma
A1 Morales Fernández, Laura
A1 Benito Pascual, Blanca
A1 Pérez García, Pilar
A1 Perucho González, Lucía
A1 Sáenz Francés, Federico
A1 Santos Bueso, Enrique Miguel
A1 García Bella, Javier
A1 Sánchez Jean, Rubén
A1 García Feijoo, Julián
A1 Martínez De La Casa Fernández-Borrella, José María
AB Objective: To describe corneal densitometry, topographic measurements, and biomechanical properties in patients with primary congenital glaucoma (PCG) and healthy patients. To examine correlations between variables and determine their glaucoma diagnostic capacity.Methods: This was a cross-sectional, case-control study conducted in 50 eyes of 50 patients with PCG (G1) and 40 eyes of 40 healthy patients (G2). The variables determined in each participant were: intraocular pressure, best corrected visual acuity (BCVA), corneal densitometry, topographic data using the Pentacam HR-Scheimpflug imaging system (Oculus Optikgerate GmbH, Wetzlar, Germany), and corneal hysteresis (CH) and corneal resistance factor (CRF) using the Ocular Response Analyzer (Reichert Ophthalmic Instruments, Depew, NY).Results: Overall densitometry was significatively higher in the PCG group (G1: 17.94 ± 4.99 vs G2: 13.25 ± 1.96, p < 0.001). CH (G1: 8.02 ± 11.35 vs G2: 11.35 ± 1.42, p < 0.001) and CRF (G1: 9.48 ± 2.83 vs G2: 10.77 ± 1.34, p < 0.001) were lower in the glaucoma group. Mean posterior, central, and anterior elevation and mean keratometry were higher in G1 (p < 0.05). In the PCG group, overall densitometry showed significant correlation with CH (r = –0.321, p = 0.028) and with BCVA (r = −0.498, p = 0.002). AUCs (areas under the curve) for CH and overall densitometry were high (0.839 and 0.899 respectively) and the best overall densitometry; CH and CRF cutoffs were 14.0, 9.3 and 9.2 respectively.Conclusion: Densitometry is increased, and biomechanical corneal properties are decreased in patients with PCG. Densitometry and visual acuity showed a negative and significant correlation, so this measurement could be used as an indirect parameter of BCVA in the clinical practice.
PB Canadian Ophthalmology Society; Elsevier
SN 1715-3360
YR 2021
FD 2021-02-10
LK https://hdl.handle.net/20.500.14352/7987
UL https://hdl.handle.net/20.500.14352/7987
LA eng
NO Morales Fernández, L., Benito Pascual, B., Pérez García, P. et al. «Corneal Densitometry and Biomechanical Properties in Patients with Primary Congenital Glaucoma». Canadian Journal of Ophthalmology, vol. 56, n.o 6, diciembre de 2021, pp. 364-70. DOI.org (Crossref), https://doi.org/10.1016/j.jcjo.2021.01.009.
DS Docta Complutense
RD 21 jul 2024