RT Journal Article
T1 Cannabinoid signalling in the immature brain: Encephalopathies and neurodevelopmental disorders
A1 Sagredo Ezquioga, Onintza
A1 Palazuelos Diego, Javier
A1 Gutierrez-Rodriguez, Ana
A1 Satta, Valentina
A1 Galve Roperh, Ismael
A1 Martínez Orgado, José Antonio
AB The endocannabinoid system exerts a crucial neuromodulatory role in many brain areas that is essential for proper regulation of neuronal activity. The role of cannabinoid signalling controlling neuronal activity in the adult brain is also evident when considering its contribution to adult brain insults or neurodegenerative diseases. In the context of brain genetic or acquired encephalopathies administration of cannabinoid-based molecules has demonstrated to exert symptomatic relief and hence, they are proposed as new potential therapeutic compounds. This review article summarizes the main evidences indicating the beneficial action of cannabinoid-derived molecules in preclinical models of neonatal hypoxia/ischemic damage. In a second part, we discuss the available evidences of therapeutic actions of cannabidiol in children with refractory epilepsy syndromes. Finally, we discuss the current view of cannabinoid signalling mechanisms active in the immature brain that affect in neural cell fate and can contribute to long-term neural cell plasticity.
PB Elsevier
SN 0006-2952
YR 2018
FD 2018-08-15
LK https://hdl.handle.net/20.500.14352/88996
UL https://hdl.handle.net/20.500.14352/88996
LA eng
NO Ministerio de Economía y Competitividad  (MINECO)/Fondo Europeo de desarrollo Regional (FEDER)
NO Comunidad de Madrid
NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional (FEDER)
NO GW Research Ltd
NO Universidad Complutense de Madrid (UCM)/Banco de Santander
DS Docta Complutense
RD 22 jul 2024