RT Journal Article
T1 Components of the glutathione cycle as markers of biological age: an approach to clinical application in aging
A1 Díaz del Cerro, Estefanía
A1 Martínez De Toda Cabeza, Irene
A1 Félix, Judith
A1 Baca, Adriana
A1 Fuente Del Rey, María Mónica De La
AB The oxidative-inflammatory theory of aging states that aging is the result of the establishment of a chronic oxidative-inflammatory stress situation in which the immune system is implicated. Among the redox parameters, those involved in the glutathione cycle have been suggested as essential in aging. Thus, the first objective of this study was to determine if several components of the glutathione cycle (glutathione reductase (GR) and glutathione peroxidase (GPx) activities, and concentrations of oxidized glutathione (GSSG) and reduced glutathione (GSH)) in leukocytes) are associated with the biological age (ImmunolAge) estimated using the Immunity Clock in 190 men and women. The second objective was to identify the best blood fraction (whole blood, blood cells, erythrocytes, or plasma) to quantify these components and correlate them with the estimated ImmunolAge. The results show that the oxidative state of peripheral leukocytes correlates with their functionality, supporting the idea that this is the basis of immunosenescence. In blood, the correlations are more significant in the fraction of blood cells with respect to ImmunolAge (positive correlations with GSSG concentration and the GSSG/GSH ratio, and negative correlations with GPx and GR activities). Therefore, blood cells are proposed as the most effective sample to estimate the biological age of individuals in clinical settings.
PB MDPI
SN 2076-3921
YR 2023
FD 2023-07-30
LK https://hdl.handle.net/20.500.14352/104693
UL https://hdl.handle.net/20.500.14352/104693
LA eng
NO Diaz-Del Cerro, E.; Martinez de Toda, I.; Félix, J.; Baca, A.; De la Fuente, M. Components of the Glutathione Cycle as Markers of Biological Age: An Approach to Clinical Application in Aging. Antioxidants 2023, 12, 1529. https://doi.org/10.3390/antiox12081529
NO 2023 Descuento MDPI
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 3 ago 2025