RT Journal Article
T1 Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study
A1 Benito León, Julián
A1 Pino, Ana Belén del
A1 Aladro, Yolanda
A1 Cuevas, Constanza
A1 Domingo-Santos, Ángela
A1 Galán Sánchez-Seco, Victoria
A1 Labiano-Fontcuberta, Andrés
A1 Gómez-López, Ana
A1 Salgado-Cámara, Paula
A1 Costa-Frossard, Lucienne
A1 Monreal, Enrique
A1 Sainz de la Maza, Susana
A1 Matias-Guiu Antem, Jordi
A1 Matías-Guiu Guía, Jorge
A1 Delgado Álvarez, Alfonso
A1 Montero-Escribano, Paloma
A1 Martínez-Ginés, María Luisa
A1 Higueras Hernández, Yolanda
A1 Ayuso-Peralta, Lucía
A1 Malpica, Norberto
A1 Melero Carrasco, Helena
AB Background: Radiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS. Objective: To examine functional connectivity differences between RIS and healthy controls using resting-state functional magnetic resonance imaging (fMRI). Methods: Resting-state fMRI data in 25 RIS patients and 28 healthy controls were analyzed using an independent component analysis; in addition, seed-based correlation analysis was used to obtain more information about specific differences in the functional connectivity of resting-state networks. Participants also underwent neuropsychological testing. Results: RIS patients did not differ from the healthy controls regarding age, sex, and years of education. However, in memory (verbal and visuospatial) and executive functions, RIS patients’ cognitive performance was significantly worse than the healthy controls. In addition, fluid intelligence was also affected. Twelve out of 25 (48%) RIS patients failed at least one cognitive test, and six (24.0%) had cognitive impairment. Compared to healthy controls, RIS patients showed higher functional connectivity between the default mode network and the right middle and superior frontal gyri and between the central executive network and the right thalamus ( p<jats:sub>FDR</jats:sub> &lt; 0.05; corrected). In addition, the seed-based correlation analysis revealed that RIS patients presented higher functional connectivity between the posterior cingulate cortex, an important hub in neural networks, and the right precuneus. Conclusion: RIS patients had abnormal brain connectivity in major resting-state neural networks and worse performance in neurocognitive tests. This entity should be considered not an “incidental finding” but an exclusively non-motor (neurocognitive) variant of multiple sclerosis.
PB SAGE
SN 1352-4585
SN 1477-0970
YR 2023
FD 2023-09
LK https://hdl.handle.net/20.500.14352/103893
UL https://hdl.handle.net/20.500.14352/103893
LA eng
NO Benito-León J, del Pino AB, Aladro Y, et al. Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study. Multiple Sclerosis Journal. 2023;29(11-12):1393-1405. doi:10.1177/13524585231195851
NO National Institutes of Health (EEUU)
NO European Commission
NO Ministerio de Economía y Competitividad (España)
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 27 dic 2025