RT Journal Article
T1 The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL‐1 through ERM proteins
A1 Domínguez‐Luis, Maria
A1 Lamana Domínguez, Amalia
A1 Vazquez, Jesús
A1 García‐Navas, Rósula
A1 Mollinedo, Faustino
A1 Sánchez‐Madrid, Francisco
A1 Díaz‐González, Federico
A1 Urzainqui, Ana
AB The P-selectin glycoprotein ligand-1 (PSGL-1) is involved in the initial contact of leukocytes with activated endothelium, and its adhesive function is regulated through its proteolytic processing. We have found that the metalloprotease ADAM8 is both associated with PSGL-1 through the ezrin–radixin–moesin actin-binding proteins and able to cause the proteolytic cleavage of this adhesion receptor. Accordingly, ADAM8 knockdown increases PSGL-1 expression, and functional assays show that ADAM8 is able to reduce leukocyte rolling on P-selectin and hence on activated endothelial cells. We conclude that ADAM8 modulates the expression and function of PSGL-1.
PB Wiley
SN 0014-2980
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/94451
UL https://hdl.handle.net/20.500.14352/94451
LA eng
NO Domínguez‐Luis, Maria, et al. «The Metalloprotease ADAM8 Is Associated with and Regulates the Function of the Adhesion Receptor PSGL‐1 through ERM Proteins». European Journal of Immunology, vol. 41, n.o 12, diciembre de 2011, pp. 3436-42. https://doi.org/10.1002/eji.201141764.
NO This work was supported by grants from the Spanish Ministry of Health (Fondo de Investigaciones Sanitarias) to A. Urzainqui (FIS-PI080894) and to F. Díaz González (FIS 09/02209), by grants from Ministerio de Ciencia e Innovación to F. S. M. (SAF2008-02635) and to F. M. (SAF2008-02251) and by the Redes RIER, RTICC (RD06/0020/1037) and RECAVA del Instituto de Salud Carlos III and RTICCR.
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de Salud Carlos III
NO Ministerio de Sanidad (España)
DS Docta Complutense
RD 9 abr 2025