RT Journal Article
T1 Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome
A1 Sol, Joaquim
A1 Elia, Òbis
A1 Mota Martorell, Natalia
A1 Pradas, Irene
A1 Galo Licona, Jose Daniel
A1 Martín Gari, Meritxell
A1 Fernández Bernal, Anna
A1 Ortega Bravo, Marta
A1 Mayneris Perxachs, Jordi
A1 Borrás, Consuelo
A1 Viña, José
A1 Fuente Del Rey, María Mónica De La
A1 Mate, Ianire
A1 Biarnes, Carles
A1 Pedraza, Salvador
A1 Vilanova, Joan
A1 Brugada, Ramón
A1 Ramos, Rafel
A1 Serena, Joaquín
A1 Ramió Torrentà, Lluís
A1 Pineda, Víctor
A1 Daunis I Estadella, Pepus
A1 Thió Henestrosa, Santiago
A1 Barretina, Jordi
A1 Garre Olmo, Josep
A1 Portero-Otin, Manuel
A1 Fernández Real, José Manuel
A1 Puig, Josep
A1 Jové, Mariona
A1 Pamplona, Reinald
AB Aging biology entails a cell/tissue deregulated metabolism that affects all levels of biological organization. Therefore, the application of “omic” techniques that are closer to phenotype, such as metabolomics, to the study of the aging process should be a turning point in the definition of cellular processes involved. The main objective of the present study was to describe the changes in plasma metabolome associated with biological aging and the role of sex in the metabolic regulation during aging. A high-throughput untargeted metabolomic analysis was applied in plasma samples to detect hub metabolites and biomarkers of aging incorporating a sex/gender perspective. A cohort of 1030 healthy human adults (45.9% females, and 54.1% males) from 50 to 98 years of age was used. Results were validated using two independent cohorts (1: n = 146, 53% females, 30–100 years old; 2: n = 68, 70% females, 19–107 years old). Metabolites related to lipid and aromatic amino acid (AAA) metabolisms arose as the main metabolic pathways affected by age, with a high influence of sex. Globally, we describe changes in bioenergetic pathways that point to a decrease in mitochondrial β-oxidation and an accumulation of unsaturated fatty acids and acylcarnitines that could be responsible for the increment of oxidative damage and inflammation characteristic of this physiological process. Furthermore, we describe for the first time the importance of gut-derived AAA catabolites in the aging process describing novel biomarkers that could contribute to better understand this physiological process but also age-related diseases.
PB Wiley 
SN 1474-9718
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/88602
UL https://hdl.handle.net/20.500.14352/88602
LA eng
NO Sol, Joaquim, et al. «Plasma Acylcarnitines and Gut‐derived Aromatic Amino Acids as Sex‐specific Hub Metabolites of the Human Aging Metabolome». Aging Cell, vol. 22, n.o 6, junio de 2023, p. e13821. https://doi.org/10.1111/acel.13821.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Generalitat de Catalunya
NO Instituto de Salud Carlos III
NO Fundación “la Caixa”
DS Docta Complutense
RD 6 abr 2025