RT Journal Article
T1 The role and therapeutic potential of melatonin in age-related ocular diseases
A1 Crooke Álvarez, Almudena
A1 Huete Toral, Fernando
A1 Colligris, Basilio
A1 Pintor Just, Jesús Jerónimo
AB The eye is continuously exposed to solar UV radiation and pollutants, making it prone to oxidative attacks. In fact, oxidative damage is a major cause of age-related ocular diseases including cataract, glaucoma, age-related macular degeneration and diabetic retinopathy. Since the nature of lens cells, trabecular meshwork cells, retinal ganglion cells, retinal pigment epithelial cells and photoreceptors is post-mitotic, autophagy plays a critical role in their cellular homeostasis. In age-related ocular diseases, this process is impaired, thus, oxidative damage becomes irreversible. Other conditions such as low- grade chronic inflammation and angiogenesis also contribute to the development of retinal diseases (glaucoma, age-related macular degeneration and diabetic retinopathy). As melatonin is known to have remarkable qualities such as antioxidant/antinitridergic, mitochondrial protector, autophagy modulator, anti-inflammatory and anti-angiogenic, it can represent a powerful tool to counteract all these diseases. The present review analyzes the role and therapeutic potential of melatonin in age-related ocular diseases, focusing on nitro-oxidative stress, autophagy, inflammation and angiogenesis mechanisms.
PB Wiley
SN 1600-079X
YR 2017
FD 2017-06-28
LK https://hdl.handle.net/20.500.14352/17894
UL https://hdl.handle.net/20.500.14352/17894
LA eng
NO Crooke Álvarez, A., Huete Toral, F., Colligris, B. et al. «The Role and Therapeutic Potential of Melatonin in Age‐related Ocular Diseases». Journal of Pineal Research, vol. 63, n.o 2, septiembre de 2017, p. e12430. DOI.org (Crossref), https://doi.org/10.1111/jpi.12430.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Universidad Complutense de Madrid
NO Redes Cooperativas de Investigación en Ciencias de la Salud
DS Docta Complutense
RD 8 abr 2025