RT Journal Article
T1 Persistent post-discharge symptoms after COVID-19 in rheumatic and musculoskeletal diseases
A1 Leon, Leticia
A1 Perez Sancristobal, Ines
A1 Madrid, Alfredo
A1 López Pedraza, Leticia
A1 Colomer, Jose Ignacio
A1 Lerma, Sergio
A1 Lois, Pia
A1 Mucientes, Arkaitz
A1 Rodríguez Rodríguez, Luis Pablo
A1 Fernández Gutiérrez, Benjamín
A1 Abasolo, Lydia
AB Objectives. We aimed to describe persistent symptoms and sequelae in patients with rheumatic andmusculoskeletal diseases (RMD) after admission owing to coronavirus disease 2019 (COVID-19),assessing the role of autoimmune rheumatic diseases (ARDs) compared with non-autoimmune rheumatic and musculoskeletal diseases (NARDs) on persistent symptoms and sequelae.Methods. We performed an observational study including RMD patients who attended a rheumatology clinic in Madrid and required admission owing to COVID-19 (between March and May 2020) and survived. The study began at discharge and ran until October 2020. Main outcomes were persistence of symptoms and sequelae related to COVID-19. The independent variable was the RMD group (ARD and NARD). Covariates included sociodemographics, clinical and treatment data. We ran a multivariate logistic regression model to assess the risk of the main outcomes by RMD group.Results. We included 105 patients, of whom 51.5% had ARD and 68.57% reported at least one persistent symptom. The most frequent symptoms were dyspnoea, fatigue and chest pain. Sequelae were recorded in 31 patients. These included lung damage in 10.4% of patients, lymphopenia in 10%, a central retinal vein occlusion and an optic neuritis. Two patients died. Eleven patients required re-admission owing to COVID-19 problems (16.7% ARD vs 3.9% NARD; P ¼ 0.053). No statistically significant differences were found between RMD groups in the final models.Conclusion. Many RMD patients have persistent symptoms, as in other populations. Lung damage is the most frequent sequela. Compared with NARD, ARD does not seem to differ in terms of persistent symptoms or consequences, although ARD might have more re-admissions owing to COVID-19.
PB Oxford University Press
YR 2022
FD 2022-02-17
LK https://hdl.handle.net/20.500.14352/133267
UL https://hdl.handle.net/20.500.14352/133267
LA eng
NO Leticia Leon, Ines Perez-Sancristobal, Alfredo Madrid, Leticia Lopez-Pedraza, Jose Ignacio Colomer, Sergio Lerma, Pia Lois, Arkaitz Mucientes, Luis Rodriguez-Rodriguez, Benjamin Fernandez-Gutierrez, Lydia Abasolo, Persistent post-discharge symptoms after COVID-19 in rheumatic and musculoskeletal diseases, Rheumatology Advances in Practice, Volume 6, Issue 1, 2022, rkac008, https://doi.org/10.1093/rap/rkac008
NO Instituto de Salud Carlos III (ISCIII)
NO Ministerio de Sanidad (España) (CP16/ 00916; PI18/01188; y RD16/0012/0014)
DS Docta Complutense
RD 24 mar 2026