RT Journal Article
T1 A systematic review of lifestyle-based interventions for managing Alzheimer's  disease: Insights from randomized controlled trials.
A1 Martínez López, Sara
A1 Tabone, Mariangela
A1 Clemente-Velasco, Sara
A1 González Soltero, María del Rocío
A1 Bailén, María
A1 Lucas, Beatriz de
A1 Bressa, Carlo
A1 Domínguez Balmaseda, Diego
A1 Marín Muñoz, Juan
A1 Antúnez, Carmen
A1 Gálvez, 
A1 González Gálvez, Beatriz
A1 Larrossa, 
A1 Larrosa Pérez, María Del Mar
AB BACKGROUND: Alzheimer's disease (AD) presents a significant challenge in healthcare, prompting exploration into non-pharmacological interventions to  complement traditional treatments. OBJECTIVE: This systematic review explores the efficacy of lifestyle-based interventions in managing AD.METHODS: A comprehensive literature search was conducted in PubMed, Web of Science, and Scopus between 2018 and 2023, selecting randomized controlled trials examining factors such as exercise, diet, stress, and cognitive training in AD patients.RESULTS: The review revealed physical exercise as the predominant non-pharmacological intervention, accompanied by dietary modifications, cognitive training, and therapies such as mindfulness and music. While exercise demonstrated improvements in quality of life, its cognitive benefits were limited. Modified diets, such as Atkins and ketogenic, displayed inconsistent effects on cognitive function but influenced other health-related parameters. Additionally, probiotic therapy and novel cognitive training technologies were explored.CONCLUSIONS: Despite some interventions showing promise in enhancing cognitive function and slowing disease progression, uncertainties remain regarding the dose-response relationship, underlying mechanisms, and potential synergistic effects. Moreover, consideration of genetic and sex-based disparities is warranted. This synthesis underscores the need for further research to elucidate the nuances of non-pharmacological interventions in managing AD effectively.
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/121252
UL https://hdl.handle.net/20.500.14352/121252
LA eng
NO Martínez-López S, Tabone M, Clemente-Velasco S, González-Soltero MDR, Bailén M, De Lucas B, et al. A systematic review of lifestyle-based interventions for managing Alzheimer’s disease: Insights from randomized controlled trials. Journal of Alzheimer’s Disease [Internet]. diciembre de 2024 [citado 12 de junio de 2025];102(4):943-66. Disponible en: https://journals.sagepub.com/doi/10.1177/13872877241292829
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 19 dic 2025