RT Journal Article
T1 Potential risk to brain health after surgical interventions: biomarkers to predict the occurrence of cognitive decline
A1 Rey Picazo, Julio
A1 Pita, Jimena
A1 Peña, Lucía
A1 Ferraz Torres, Marta
A1 Martínez García, Oscar
A1 Ávila Villanueva, Marina
A1 Santos Pérez, Gloria
A1 López Sanz, David
A1 Moreno Arribas, M. Victoria
A1 González Perrino, Carlos
A1 Muedra, Vicente
A1 Miñano Molina, Alfredo Jesús
A1 Hernández Rabaza, Vicente
A1 Gómez Pinedo, Ulises
A1 León Espinosa, Gonzalo
AB As the global population ages, the number of people living with dementia is projected to increase significantly. Estimations indicate that over 150 million people worldwide will be living with dementia by 2050, with Alzheimer’s disease being the most common cause. Elderly people are also at greater risk of undergoing surgery, either elective or emergency, escalating the associated likelihood leading to cognitive decline, especially if accumulative. However, the relationship between surgery and dementia development remains controversial. The cause seems to lie in the heterogeneous preoperative state of subjects participating in research studies. Interpreting and comparing the results of these studies could be an arduous task due to variables such as medication, follow-up time, type of surgery and anesthesia, duration and invasiveness of the surgical intervention, differential neuroinflammatory response, the patient metabolic/biochemical status or if there are comorbidities. Considering the complexity of this type of studies, the present review summarizes the most important factors/biomarkers that could provide useful information for pre- and post-operative medical decision making in relation to the development of dementia. Emphasis will be placed on the relationship between temperature, Tau phosphorylation, whose plasma detection as an early diagnostic factor is gaining great relevance, and other neurodegenerative biomarker interplay. The prolonged maintenance of key biomarkers in blood could be detrimental and, therefore, a more comprehensive individualized hospital study may improve the prevention of postoperative complications.
PB Aging and Disease Editorial
YR 2025
FD 2025-10
LK https://hdl.handle.net/20.500.14352/130629
UL https://hdl.handle.net/20.500.14352/130629
LA eng
NO Julio Rey-Picazo , Jimena Pita , Lucía Peña , Marta Ferraz-Torres , Oscar Martínez-García , Marina Ávila-Villanueva , Gloria Santos-Pérez , David López-Sanz , M. Victoria Moreno-Arribas , Carlos González Perrino , Vicente Muedra , Alfredo Jesús Miñano-Molina , Vicente Hernández-Rabaza , Ulises Gómez-Pinedo , Gonzalo León-Espinosa. Potential Risk to Brain Health after Surgical Interventions: Biomarkers to Predict the Occurrence of Cognitive Decline. Aging and disease. 2025 https://doi.org/10.14336/AD.2025.1105
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 26 feb 2026