RT Journal Article
T1 Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells
A1 Castro Vázquez, David
A1 Arribas Castaño, Paula
A1 García López, Iván
A1 Gutiérrez Cañas, Irene
A1 Pérez García, Selene
A1 Lamana Domínguez, Amalia
A1 Villanueva Romero, Raúl
A1 Cabrera Martín, Alicia
A1 Tecza, Karolina
A1 Martínez Mora, María Del Carmen
A1 Juarranz Moratilla, Yasmina
A1 Pérez Gomáriz, Rosa María
A1 Carrión Caballo, Mar
AB Several neuropeptides present in bone tissues, produced by nerve fibers and bone cells, have been reported to play a role in regulating the fine-tuning of osteoblast and osteoclast functions to maintain bone homeostasis. This study aims to characterize the influence of the neuropeptide vasoactive intestinal peptide (VIP) on the differentiation process of human mesenchymal stem cells (MSCs) into osteoblasts and on their anabolic function. We describe the mRNA and protein expression profile of VIP and its receptors in MSCs as they differentiate into osteoblasts, suggesting the presence of an autocrine signaling pathway in these cells. Our findings reveal that VIP enhances the expression of early osteoblast markers in MSCs under osteogenic differentiation and favors both bone matrix formation and proper cytoskeletal reorganization. Finally, our data suggest that VIP could be exerting a direct modulatory role on the osteoblast to osteoclast signaling by downregulating the receptor activator of nuclear factor-κB ligand/osteoprotegerin ratio. These results highlight the potential of VIP as an osteoinductive differentiation factor, emerging as a key molecule in the maintenance of human bone homeostasis.
PB Wiley
SN 0951-6433
YR 2024
FD 2024-05-11
LK https://hdl.handle.net/20.500.14352/104281
UL https://hdl.handle.net/20.500.14352/104281
LA eng
NO Castro-Vázquez D, Arribas-Castaño P, García-López I, Gutiérrez-Cañas I, Pérez-García S, Lamana A, Villanueva-Romero R, Cabrera-Martín A, Tecza K, Martínez C, Juarranz Y, Gomariz RP, Carrión M. Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells. Biofactors. 2024 May 11. doi: 10.1002/biof.2062. Epub ahead of print. PMID: 38733572.
NO Financiado con el Fondo Europeo de Desarrollo Regional (FEDER)
NO Ministerio de Economía y Competitividad (España)
NO European Commission
NO Instituto de Salud Carlos III (España)
DS Docta Complutense
RD 21 mar 2026