RT Journal Article
T1 Neuroestradiol and neuronal development: not an exclusive male tale anymore
A1 García Segura, Luis M.
A1 Méndez, Pablo
A1 Arévalo, M. Angeles
A1 Azcoitia Elías, Íñigo
AB The brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain development. In addition, recent findings have shown sex-specific actions of neuroestradiol on neuroblast migration, neuritic growth and synaptogenesis in females. Among other factors, the epigenetic regulation exerted by X linked genes, such as Kdm6a/Utx, may determine sex-specific actions of neuroestradiol in the female brain. This review evidences the impact of neuroestradiol on brain formation in both sexes and highlights the interaction of neural steriodogenesis, hormones and sex chromosomes in sex-specific brain development.
PB Elsevier
SN 0091-3022
YR 2023
FD 2023-09
LK https://hdl.handle.net/20.500.14352/121508
UL https://hdl.handle.net/20.500.14352/121508
LA eng
NO García-Segura LM, Méndez P, Arevalo MA, Azcoitia I. Neuroestradiol and neuronal development: Not an exclusive male tale anymore. Frontiers in Neuroendocrinology 2023;71:101102. https://doi.org/10.1016/j.yfrne.2023.101102.
NO Funding:This study has been supported by Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain and by PID2020-115019RB-I00 and PID2020-112824GB-I00 funded by MCIN/AEI/ https://doi.org/10.13039/501100011033 and Fondo Europeo de Desarrollo Regional (FEDER).
NO European Commission
NO Ministerio de Ciencia e Innovación (España)
NO Agencia Estatal de Investigación (España)
NO Instituto de Salud Carlos III (España)
DS Docta Complutense
RD 7 jun 2026