RT Journal Article
T1 Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats
A1 Anadón Navarro, Arturo Ramón
A1 Martínez Larrañaga, María Rosa
A1 Martínez Caballero, María Aranzazu
A1 Castellano Santos, Víctor Jesús
A1 Martínez Caballero, Marta
A1 Martín, M.T.
A1 Nozal, M.J.
A1 Bernal, J.L.
AB The toxicokinetics of glyphosate after single 100 mg kg−1 intravenous (i.v.) and 400 mg kg−1 oral doses were studied in rats. Serial blood samples were obtained after i.v. and oral administration. Plasma concentrations of glyphosate and its metabolite amiomethyl phosphonic acid (AMPA) were determined by HPLC method. After i.v. and oral administration, plasma concentration–time curves were best described by a two-compartment open model. For glyphosate, the elimination half-lives (T1/2β) from plasma were 9.99 h after i.v. and 14.38 h after oral administration. The total plasma clearance was not influenced by dose concentration or route and reached a value of 0.995 l h−1 kg−1. After i.v. administration, the apparent volume of distribution in the second compartment (V2) and volume of distribution at steady state (Vss) were 2.39 and 2.99 l kg−1, respectively, suggesting a considerable diffusion of the herbicide into tissues. After oral administration, glyphosate was partially and slowly absorbed with a Tmax of 5.16 h. The oral bioavailability of glyphosate was found to be 23.21%. Glyphosate was converted to AMPA. The metabolite AMPA represented 6.49% of the parent drug plasma concentrations. The maximum plasma concentrations of glyphosate and AMPA were 4.62 and 0.416 μg ml−1, respectively. The maximum plasma concentration of AMPA was achieved at 2.42 h. For AMPA, the elimination half-life (T1/2β) was 15.08 h after oral administration of glyphosate parent compound.
PB Elsevier
SN 0378-4274
YR 2009
FD 2009-10-08
LK https://hdl.handle.net/20.500.14352/97992
UL https://hdl.handle.net/20.500.14352/97992
LA eng
NO Anadón A, Martínez-Larrañaga MR, Martínez MA, Castellano VJ, Martínez M, Martin MT, Nozal MJ, Bernal JL. Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats. Toxicol Lett. 2009 Oct 8;190(1):91-5. doi: 10.1016/j.toxlet.2009.07.008. Epub 2009 Jul 14. PMID: 19607892
DS Docta Complutense
RD 30 dic 2025