RT Journal Article
T1 Entry Inhibitors Directed Towards Glycoprotein gp120: An Overview on a Promising Target for HIV-1 Therapy
A1 Flores Aguilar-Amat, Aída
A1 Quesada del Sol, Ernesto
AB In spite of the unquestionable positive impact of HAART in the treatment of HIV infection, the discovery and development of novel agents directed towards other targets of the replicative cycle of the virus that differ from those targeted by the clinically approved drugs, emerges nowadays as an imperative need. The blockade of HIV entry is a highly promising strategy against the pathogen and glycoprotein gp120 is a central actor in this process. This review discusses the current status in the research of anti-HIV agents targeting specifically the envelope protein gp120. The diverse approaches devoted to the achievement of therapeutic agents against gp120 currently under study are organized and analyzed critically according to their specific mechanism of inhibition and structural features.
PB Bentham Science
YR 2013
FD 2013-02-01
LK https://hdl.handle.net/20.500.14352/100078
UL https://hdl.handle.net/20.500.14352/100078
LA eng
NO Flores A, Quesada E. Entry Inhibitors Directed Towards Glycoprotein gp120: An Overview on a Promising Target for HIV-1 Therapy. Current Medicinal Chemistry 2013;20:751–71. https://doi.org/10.2174/092986713805076676.
DS Docta Complutense
RD 22 abr 2025