RT Journal Article
T1 The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration
A1 Ladera, Carolina
A1 Godino, María del Carmen
A1 Martín Herranz, Ricardo
A1 Luján, Rafael
A1 Shigemoto, Ryuichi
A1 Ciruela, Francisco
A1 Torres Molina, Magdalena Isabel
A1 Sánchez-Prieto Borja, José
AB Excitatory synaptic transmission is inhibited by G protein coupled receptors, including the adenosine A(1), GABA(B), and metabotropic glutamate receptor 7. These receptors are present in nerve terminals where they reduce the release of glutamate through activating signaling pathways negatively coupled to Ca(2+) channels and adenylyl cyclase. However, it is not clear whether these receptors operate in distinct subpopulations of nerve terminals or if they are co-expressed in the same nerve terminals, despite the functional consequences that such distributions may have on synaptic transmission. Applying Ca(2+) imaging and immunocytochemistry, we show that these three G protein coupled receptors coexist in a subpopulation of cerebrocortical nerve terminals. The three receptors share an intracellular signaling pathway through which their inhibitory responses are integrated and coactivation of these receptors produced an integrated response. Indeed, this response was highly variable, from a synergistic response at subthreshold agonist concentrations to an occluded response at high agonist concentrations. The presence of multiple receptors in a nerve terminal could be responsible for the physiological effects of neurotransmitter spillover from neighboring synapses or alternatively, the co-release of transmitters by the same nerve terminal
PB Wiley
SN 0022-3042
YR 2007
FD 2007
LK https://hdl.handle.net/20.500.14352/97907
UL https://hdl.handle.net/20.500.14352/97907
LA eng
NO Ladera, Carolina, et al. «The Coexistence of Multiple Receptors in a Single Nerve Terminal Provides Evidence for Pre‐synaptic Integration». Journal of Neurochemistry, vol. 103, n.o 6, diciembre de 2007, pp. 2314-26. https://doi.org/10.1111/j.1471-4159.2007.04964.x.
NO Ministerio de Educación y Ciencia (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 13 abr 2025