%0 Journal Article
%A Favuzzi, Emilia
%A Marques Smith, André
%A Deogracias, Rubén
%A Winterflood, Christian M.
%A Sánchez-Aguilera López, Alberto
%A Mantoan, Laura
%A Maeso, Patricia
%A Fernandes, Cathy
%A Ewers, Helge
%A Rico, Beatriz
%T Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican
%D 2017
%U https://hdl.handle.net/20.500.14352/94949
%X Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function
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