RT Journal Article
T1 Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican
A1 Favuzzi, Emilia
A1 Marques Smith, André
A1 Deogracias, Rubén
A1 Winterflood, Christian M.
A1 Sánchez-Aguilera López, Alberto
A1 Mantoan, Laura
A1 Maeso, Patricia
A1 Fernandes, Cathy
A1 Ewers, Helge
A1 Rico, Beatriz
AB Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function
PB Cell Press
YR 2017
FD 2017-07
LK https://hdl.handle.net/20.500.14352/94949
UL https://hdl.handle.net/20.500.14352/94949
LA eng
NO Emilia Favuzzi, André Marques-Smith, Rubén Deogracias, Christian M Winterflood, Alberto Sánchez-Aguilera, Laura Mantoan, Patricia Maeso, Cathy Fernandes, Helge Ewers, Beatriz Rico. Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron . 2017 Aug 2;95(3):639-655.e10. (Epub 2017 Jul 14)
DS Docta Complutense
RD 16 abr 2025