RT Journal Article T1 Enhancing Extraction of Drug-Drug Interaction from Literature Using Neutral Candidates, Negation, and Clause Dependency A1 Behrouz Bokharaeian, A1 Hamidreza Chitsaz, A1 Díaz Esteban, Alberto A2 Francisco M Couto, AB Motivation Supervised biomedical relation extraction plays an important role in biomedical natural language processing, endeavoring to obtain the relations between biomedical entities. Drug-drug interactions, which are investigated in the present paper, are notably among the critical biomedical relations. Thus far many methods have been developed with the aim of extracting DDI relations. However, unfortunately there has been a scarcity of comprehensive studies on the effects of negation, complex sentences, clause dependency, and neutral candidates in the course of DDI extraction from biomedical articles. Results Our study proposes clause dependency features and a number of features for identifying neutral candidates as well as negation cues and scopes. Furthermore, our experiments indicate that the proposed features significantly improve the performance of the relation extraction task combined with other kernel methods. We characterize the contribution of each category of features and finally conclude that neutral candidate features have the most prominent role among all of the three categories. SN 1932-6203 YR 2016 FD 2016-10-03 LK https://hdl.handle.net/20.500.14352/92388 UL https://hdl.handle.net/20.500.14352/92388 LA eng DS Docta Complutense RD 7 abr 2025