RT Journal Article
T1 Copper and Chrkomium toxicity is mediated by oxidative stress in Caenorhabditis elegans: The use of nanoparticles as an immobilization strategy
A1 Sánchez-Fortún Rodríguez, Sebastián
A1 Martín Fernández, Margarita
A1 Costa Buitrago, Gonzalo Antonio
A1 Nande Barbeitos, María Del Mar
A1 Garrido, Elena
A1 Fajardo Martínez, Carmen María
A1 Martín, Carmen
AB Environmental contamination by heavy metals (HMs) has impelled searching for stabilization strategies, where the use of zero-valent iron nanoparticles (nZVI) is considered a promising option. We have evaluated the combined effect of Cu(II)-Cr(VI) on two Caenorhabditis elegans strains (N2 and RB1072 sod-2 mutant) in aqueous solutions and in a standard soil, prior and after treatment with nZVI (5% w/w). The results showed that HMs aqueous solutions had an intense toxic effect on both strains. Production of reactive oxygen species and enhanced expression of the heat shock protein Hsp-16.2 was observed, indicating increased HM-mediated oxidative stress.Toxic effects of HM-polluted soil on worms were higher for sod-2 mutant than for N2 strain. However, nZVI treatment significantly diminished all these effects. Our findings highlighted C. elegans as a sensitive indicator for HMs pollution and its usefulness to assess the efficiency of the nanoremediation strategy to decrease the toxicity of Cu(II)-Cr(VI) polluted environments.
PB Elsevier
SN 1382-6689
YR 2022
FD 2022-03-12
LK https://hdl.handle.net/20.500.14352/72536
UL https://hdl.handle.net/20.500.14352/72536
LA eng
NO Fajardo, C., Martín, C., Garrido, E., Sánchez-Fortún, S., Nande, M., Martín, M., & Costa, G. (2022). Copper and Chromium toxicity is mediated by oxidative stress in Caenorhabditis elegans: The use of nanoparticles as an immobilization strategy. Environmental toxicology and pharmacology, 92, 103846. https://doi.org/10.1016/j.etap.2022.103846
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 25 abr 2025