%0 Journal Article
%A Castillo Romero, Rafael
%A Hernández-Escobar, David
%A Gómez Graña, Sergio
%A Vallet Regí, María Dulce Nombre
%T Reversible nanogate system for Mesoporous Silica Nanoparticles based on Diels-Alder adducts.
%D 2018
%@ 1521-3765
%U https://hdl.handle.net/20.500.14352/11979
%X The implementation of nanoparticles as nanomedicines require from sophisticated surface modifications in order to reduce immune response and enhance recognition abilities. In addition to that, Mesoporous Silica nanoparticles present extraordinary host-guest abilities and facile surface functionalization. These two factors make them ideal candidates for the development ofnovel drug delivery systems, at the expense of increasing the structural complexity. With this idea in mind, a system of triggerable and tunable silica nanoparticles was developed for its application as drug delivery nanocarriers. For that purpose, Diels-Alder cycloaddition adducts were chosen as thermalresponsive units; that permitted to bind Au nanocaps able to block the pores and allow the incorporation of targeting fragments. The capping efficiency was tested under different thermal conditions, obtaining outstanding efficiencies within the physiological range and mild temperatures, as well as enhanced releases under pulsing heating cycles which showed the best release profiles.
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