RT Journal Article
T1 Chemical composition and cytotoxic activity of the essential oil of Hinterubera imbricata species collected in Venezuelan Andes
A1 Rojas, Janne
A1 Buitrago Díaz, Alexis
A1 Rojas, Luis
A1 Arvelo, Francisco
A1 Sojo, Felipe
A1 Ramírez, Hegira
A1 Fernández Moreira, Esteban
AB Hinterhubera imbricata Cuatrec. et Aristeg belongs to Asteraceae family and it is one of the six endemic species that grows in Venezuela Andean. Present investigation aimed to determine the chemical composition of the essential oil of Hinterhubera imbricata and to evaluate the cytotoxic activity in human tumor cell lines from MCF-7 (breast carcinoma without over-expression of the HER2/cerb-2), PANC-1 (pancreatic adenocarcinoma ductal type) and SKBr3 (breast carcinoma, in which the HER2/cerb-2 gene is overexpressed). Results indicated that essential oil was mainly composed of monoterpenes being α-phellandrene, α-pinene, β-phellandrene and p-cymene as major components. Cytotoxic analysis revealed that this essential oil exhibited antitumor activity in all human tumor lines tested being more cytotoxic for the pancreatic cancer tumor line. To the best of our knowledge there are no published studies regarding either the genus Hinterhubera or the species Hinterhubera imbricata, thus, present investigation is considered as a contribution to the genus Hinterhubera study.
PB Taylor & Francis
SN 0972-060X
YR 2024
FD 2024-07-08
LK https://hdl.handle.net/20.500.14352/125144
UL https://hdl.handle.net/20.500.14352/125144
LA eng
NO Rojas, J., Díaz, A. B., Rojas, L., Arvelo, F., Sojo, F., Ramírez, H., & Fernández-Moreirag, E. (2024). Chemical composition and cytotoxic activity of the essential oil of Hinterubera imbricata species collected in Venezuelan Andes. Journal of Essential Oil Bearing Plants, 27(4), 1071–1078. https://doi.org/10.1080/0972060X.2024.2365734
DS Docta Complutense
RD 23 dic 2025