RT Journal Article
T1 Severe hypoxaemia with a left ventricular assist device in a minipig model with an undiagnosed congenital cardiac disease
A1 Quintana Villamandos, María Begoña
A1 Rodríguez Bernal, Guillermo Juan
A1 Pérez Caballero, Ramón
A1 Otero, Javier
A1 Ruiz Fernández, Manuel
A1 Delgado Martos, María Jesús
A1 Sánchez Hernández, José Javier
A1 Delgado Baeza, Emilio
A1 Cañizo López, Juan Francisco Del
AB We describe the placement of a left ventricular assist device (LVAD) in a pig with spontaneously occurring atrial septal defect (ASD) (incidental finding) that created a right-left cardiac shunt, with subsequent severe hypoxaemia. Early diagnosis was critical in order to prevent end-organ damage due to hypoxaemia. Adequate monitoring alerted us to the deterioration in oxygenation, haemodynamics and cerebral oxygen metabolism. This forced us to change the level of assistance provided by the pump, and thus dramatically correct this impairment. Necropsy revealed an ostium secundum ASD. In conclusion, if hypoxaemia presents after implementation of an LVAD, the presence of a right-left shunt must be ruled out. The first step must be a judicious reduction in assist device flow to minimize intracardiac shunting. Subsequently, atrial septal closure of the defect should be considered. We report an experimental model of severe hypoxaemia after placement of an LVAD as part of a larger research project
PB SAGE Publications
SN 0023-6772
YR 2012
FD 2012-01-01
LK https://hdl.handle.net/20.500.14352/98036
UL https://hdl.handle.net/20.500.14352/98036
LA eng
NO Quintana-Villamandos B, Rodríguez-Bernal GJ, Pérez-Caballero R, Otero J, Ruiz M, Delgado-Martos MJ, Sánchez-Hernández JJ, Delgado-Baeza E, Del Cañizo JF. Severe hypoxaemia with a left ventricular assist device in a minipig model with an undiagnosed congenital cardiac disease. Lab Anim. 2012 Jan;46(1):77-80. doi: 10.1258/la.2011.011067
NO Ministerio de Sanidad
DS Docta Complutense
RD 21 abr 2025