RT Journal Article
T1 Potential Effects of Melatonin and Micronutrients on Mitochondrial Dysfunction during a Cytokine Storm Typical of Oxidative/Inflammatory Diseases
A1 Martín Giménez, Virna Margarita
A1 Heras Jiménez, Natalia De Las
A1 Ferder, León
A1 Lahera Julia, Vicente
A1 Reiter, Russel J.
A1 Manucha, Walter
AB Exaggerated oxidative stress and hyper-inflammation are essential features of oxidative/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may prevent or attenuate mitochondrial damage and may preserve an optimal state of health by managing the general oxidative and inflammatory status. This review aims to describe the crucial role of mitochondria in the development and progression of multiple diseases as well as the close relationship among mitochondrial dysfunction, oxidative stress, and cytokine storm. Likewise, it attempts to summarize the main findings related to the powerful effects of melatonin and some micronutrients (vitamins and minerals), which may be useful (alone or in combination) as therapeutic agents in the treatment of several examples of oxidative/inflammatory pathologies, including sepsis, as well as cardiovascular, renal, neurodegenerative, and metabolic disorders.
PB MPDI
SN 2079-9721
YR 2021
FD 2021-04-14
LK https://hdl.handle.net/20.500.14352/7209
UL https://hdl.handle.net/20.500.14352/7209
LA eng
NO Martín Giménez, V. M., Heras Jiménez, N., Ferder, L. et al. «Potential Effects of Melatonin and Micronutrients on Mitochondrial Dysfunction during a Cytokine Storm Typical of Oxidative/Inflammatory Diseases». Diseases, vol. 9, n.o 2, abril de 2021, p. 30. DOI.org (Crossref), https://doi.org/10.3390/diseases9020030.
NO Research and Technology Council of Cuyo University (Argentina)
NO Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Argentina)
NO Fondo para la Investigación Científica y Tecnológica (Argentina)
DS Docta Complutense
RD 9 abr 2025