TY  - JOUR
AU  - Medina, Rocio A.
AU  - Vázquez Villa, María Del Henar
AU  - Gómez Tamayo, José C.
AU  - Benhamú Salama, Bellinda
AU  - Martín-Fontecha Corrales, María Del Mar
AU  - de la Fuente, Tania
AU  - Caltabiano, Gianluigi
AU  - Hedlund, Peter B.
AU  - Pardo, Leonardo
AU  - López Rodríguez, María Luz
PY  - 2014
DO  - 10.1021/jm500880c
SN  - 0022-2623
UR  - https://hdl.handle.net/20.500.14352/114419
T2  - Journal of Medicinal Chemistry
AB  - The finding that ergotamine binds serotonin receptors in a less conserved extended binding pocket close to the extracellular entrance, in addition to the orthosteric site, allowed us to obtain 5-HT7R antagonist 6 endowed with high affinity (Ki = 0.7...
LA  - eng
M2  - 6879
PB  - ACS Publications
KW  - GPCR
KW  - Serotonin 5-HT7 receptor
KW  - Selective antagonists
KW  - Major depression
KW  - Antidepressant-like effect
TI  - The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo
TY  - journal article
VL  - 57
ER  -