RT Journal Article
T1 X-Ray nanothermometry of nanoparticles in tumor-mimicking tissues under photothermia
A1 López Méndez, Rosalía
A1 Reguera, Javier
A1 Fromain, Alexandre
A1 Abu Serea, Esraa Samy
A1 Céspedes, Eva
A1 Teran, Francisco José
A1 Zheng, Fangyuan
A1 Parente, Ana
A1 García, Miguel Ángel
A1 Fonda, Emiliano
A1 Camarero, Julio
A1 Wilhelm, Claire
A1 Muñoz Noval, Álvaro
A1 Espinosa, Ana
AB Temperature plays a critical role in regulating body mechanisms and indicating inflammatory processes. Local temperature increments above 42 °C are shown to kill cancer cells in tumorous tissue, leading to the development of nanoparticle-mediated thermo-therapeutic strategies for fighting oncological diseases. Remarkably, these therapeutic effects can occur without macroscopic temperature rise, suggesting localized nanoparticle heating, and minimizing side effects on healthy tissues. Nanothermometry has received considerable attention as a means of developing nanothermosensing approaches to monitor the temperature at the core of nanoparticle atoms inside cells. In this study, a label-free, direct, and universal nanoscale thermometry is proposed to monitor the thermal processes of nanoparticles under photoexcitation in the tumor environment. Gold-iron oxide nanohybrids are utilized as multifunctional photothermal agents internalized in a 3D tumor model of glioblastoma that mimics the in vivo scenario. The local temperature under near-infrared photo-excitation is monitored by X-ray absorption spectroscopy (XAS) at the Au L3-edge (11 919 eV) to obtain their temperature in cells, deepening the knowledge of nanothermal tumor treatments. This nanothermometric approach demonstrates its potential in detecting high nanothermal changes in tumor-mimicking tissues. It offers a notable advantage by enabling thermal sensing of any element, effectively transforming any material into a nanothermometer within biological environments.
PB Wiley
SN 2192-2640
YR 2023
FD 2023-12-15
LK https://hdl.handle.net/20.500.14352/103026
UL https://hdl.handle.net/20.500.14352/103026
LA eng
NO 2023 Acuerdos transformativos CRUE
NO Comunidad de Madrid
NO Ministerio de Ciencia e Innovación (España)
NO Fondo Europeo de Desarrollo Regional (Unión Europea)
NO Agencia Estatal de Investigación (España)
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 21 abr 2025