RT Journal Article
T1 Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness?
A1 Carballo Belloso, Juan José
A1 Harkavy-Friedman, J
A1 Burke, AK
A1 Sher, Leo
A1 Baca García, Enrique
A1 Sullivan, GM
A1 Grunebaum, MF
A1 Parsey, RV
A1 Mann, JJ
A1 Oquendo, MA
AB Background: Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects.Methods: BD individuals with family history of suicidal behavior and personal history of childhood abuse (BD-BOTH), BD individuals with family history of suicidal behavior or personal history of childhood abuse (BD-ONE), and BD individuals with neither of these two risk factors (BD-NONE) were compared with regard to demographic variables and clinical measures.Results: Almost 70% of the sample had a history of a previous suicide attempt. There were significantly higher rates of previous suicide attempts in the BD-BOTH and BD-ONE relative to the BD-NONE group. BD-BOTH were significantly younger at the time of their first suicide attempt and had higher number of suicide attempts compared with BD-NONE. BD-BOTH were significantly younger at the time of their first episode of mood disorder and first psychiatric hospitalization and had significantly higher rates of substance use and borderline personality disorders compared to BD-NONE.Limitations: Retrospective study. Use of semi-structured interview for the assessment of risk factors.Conclusions: BD individuals with a familial liability for suicidal behavior and exposed to physical and/or sexual abuse during childhood are at a greater risk to have a more impaired course of bipolar illness and greater suicidality compared to those subjects with either only one or none of these risk factors. Prospective studies are needed to confirm these findings.
PB Elsevier
SN 0165-0327
YR 2008
FD 2008
LK https://hdl.handle.net/20.500.14352/128216
UL https://hdl.handle.net/20.500.14352/128216
LA eng
NO Carballo JJ, Harkavy-Friedman J, Burke AK, Sher L, Baca-Garcia E, Sullivan GM, Grunebaum MF, Parsey RV, Mann JJ, Oquendo MA. Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness? J Affect Disord. 2008 Jul;109(1-2):57-63
NO Dr. Carballo's work was supported by an Alicia Koplowitz Foundation Fellowship in Child and Adolescent Psychiatry
NO The study was supported by NIMH grants MH59710 and MH62185
DS Docta Complutense
RD 18 dic 2025