RT Journal Article
T1 Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy
A1 Scattolin, Thomas
A1 Tonon, Giovanni
A1 Botter, Eleonora
A1 Canale, Viviana Claudia
A1 Hasanzadeh, Mahdi
A1 Cuscela, Denise Maria
A1 Buschini, Annamaria
A1 Zarepour, Atefeh
A1 Khosravi, Arezoo
A1 Cordani, Marco
A1 Rizzolio, Flavio
A1 Zarrabi, Ali
AB This review article explores the innovative field of eco-friendly cyclodextrin-based coordination polymers and metal–organic frameworks (MOFs) for transdermal drug delivery in the case of skin cancer therapy. We critically examine the significant advancements in developing these nanocarriers, with a focus on their unique properties such as biocompatibility, targeted drug release, and enhanced skin permeability. These attributes are instrumental in addressing the limitations inherent in traditional skin cancer treatments and represent a paradigm shift towards more effective and patient-friendly therapeutic approaches. Furthermore, we discuss the challenges faced in optimizing the synthesis process for large-scale production while ensuring environmental sustainability. The review also emphasizes the immense potential for clinical applications of these nanocarriers in skin cancer therapy, highlighting their role in facilitating targeted, controlled drug release which minimizes systemic side effects. Future clinical applications could see these nanocarriers being customized to individual patient profiles, potentially revolutionizing personalized medicine in oncology. With further research and clinical trials, these nanocarriers hold the promise of transforming the landscape of skin cancer treatment. With this study, we aim to provide a comprehensive overview of the current state of research in this field and outline future directions for advancing the development and clinical application of these innovative nanocarriers.
PB Royal Society of Chemistry
SN 2050-750X
YR 2024
FD 2024-03-26
LK https://hdl.handle.net/20.500.14352/119962
UL https://hdl.handle.net/20.500.14352/119962
LA eng
NO Scattolin, T., Tonon, G., Botter, E., Canale, V. C., Hasanzadeh, M., Cuscela, D. M., Buschini, A., Zarepour, A., Khosravi, A., Cordani, M., Rizzolio, F., & Zarrabi, A. (2024). Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy. Journal of Materials Chemistry B, 12(16), 3807–3839. https://doi.org/10.1039/d4tb00312h
NO This work was supported by the University of Eastern Piedmont (Italy), the University of Trieste (Italy), the University of Parma (Italy), and the University of Ferrara (Italy).
NO University of Eastern Piedmont
NO University of Trieste
NO University of Parma
NO University of Ferrara
DS Docta Complutense
RD 18 dic 2025