%0 Journal Article
%A Janssen, Joost
%A Reig Ramellat, Rosa María
%A Parellada Redondo, María José
%A Moreno Ruiz, María del Carmen
%A Moreno Pardillo, Dolores María
%A Arango López, Celso
%A Desco, Manuel 
%T Regional specificity of thalamic volume deficits in male adolescents with early-onset psychosis
%D 2012
%U https://hdl.handle.net/20.500.14352/115199
%X Background: Thalamic volume deficits are associated with psychosis but it is unclear whether the volume reduction is uniformly distributed or whether it is more severe in particular thalamic regions.Aims: To quantify whole and regional thalamic volume in males with early-onset psychosis and healthy male controls.Method: Brain scans were obtained for 80 adolescents: 46 individuals with early-onset psychosis with a duration of positive symptoms less than 6 months and 34 healthy controls. All participants were younger than 19 years. Total thalamic volumes were assessed using FreeSurfer and FSL-FIRST, group comparisons of regional thalamic volumes were studied with a surface-based approach.Results: Total thalamic volume was smaller in participants with early-onset psychosis relative to controls. Regional thalamic volume reduction was most significant in the right anterior mediodorsal area and pulvinar.Conclusions: In males with minimally treated early-onset psychosis, thalamic volume deficits may be most pronounced in the anterior mediodorsal and posterior pulvinar regions, adding strength to findings from post-mortem studies in adults with psychosis.
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