RT Journal Article
T1 Regional specificity of thalamic volume deficits in male adolescents with early-onset psychosis
A1 Janssen, Joost
A1 Reig Ramellat, Rosa María
A1 Parellada Redondo, María José
A1 Moreno Ruiz, María del Carmen
A1 Moreno Pardillo, Dolores María
A1 Arango López, Celso
A1 Desco, Manuel
AB Background: Thalamic volume deficits are associated with psychosis but it is unclear whether the volume reduction is uniformly distributed or whether it is more severe in particular thalamic regions.Aims: To quantify whole and regional thalamic volume in males with early-onset psychosis and healthy male controls.Method: Brain scans were obtained for 80 adolescents: 46 individuals with early-onset psychosis with a duration of positive symptoms less than 6 months and 34 healthy controls. All participants were younger than 19 years. Total thalamic volumes were assessed using FreeSurfer and FSL-FIRST, group comparisons of regional thalamic volumes were studied with a surface-based approach.Results: Total thalamic volume was smaller in participants with early-onset psychosis relative to controls. Regional thalamic volume reduction was most significant in the right anterior mediodorsal area and pulvinar.Conclusions: In males with minimally treated early-onset psychosis, thalamic volume deficits may be most pronounced in the anterior mediodorsal and posterior pulvinar regions, adding strength to findings from post-mortem studies in adults with psychosis.
PB Cambridge University Press
YR 2012
FD 2012-01-18
LK https://hdl.handle.net/20.500.14352/115199
UL https://hdl.handle.net/20.500.14352/115199
LA eng
NO Janssen J, Alemán-Gómez Y, Reig S, Schnack HG, Parellada M, Graell M, Moreno C, Moreno D, Mateos-Pérez JM, Udias JM, Arango C, Desco M. Regional specificity of thalamic volume deficits in male adolescents with early-onset psychosis. Br J Psychiatry. 2012 Jan;200(1):30-6. doi: 10.1192/bjp.bp.111.093732
DS Docta Complutense
RD 10 abr 2025