RT Journal Article
T1 Influence of the Human Development Index on the Maternal–Perinatal Morbidity and Mortality of Pregnant Women with SARS-CoV-2 Infection: Importance for Personalized Medical Care
A1 Cuñarro López, Yolanda
A1 Garcia Tizon Larroca, Santiago
A1 Pintado Recarte, Pilar
A1 Hernández Martín, Concepción
A1 Prats Rodríguez, Pilar
A1 Cano Valderrama, Óscar
A1 Cueto Hernández, Ignacio
A1 Ruiz Labarta, Javier
A1 Muñóz Chápuli, María del Mar
A1 Martínez Pérez, Óscar
A1 Ortega, Miguel Angel
A1 De León Luis, Juan Antonio
AB Coronavirus disease-19 (COVID-19) is perhaps the most worrisome pandemic in the 21st century, having entailed devastating consequences for the whole society during the last year. Different studies have displayed an existing association between pregnancy and COVID-19 severity due to the various physiological changes that occur during gestation. Recent data identified maternal country of origin as an important determinant of COVID-19 presentation in pregnant women. However, the explanation of this fact remains to be fully elucidated. Therefore, the purpose of this work is to analyze the possible relationship between Human Development Index (HDI) of maternal country of origin with the morbimortality of pregnant women and their newborns. Here, we conducted a multicentric, ambispective, observational case-control study (1:1 ratio) and compare with the HDI of each country (group 1—very high HDI, group 2—high HDI, group 3—medium HDI, and group 4—low HDI). In total, 1347 pregnant women with confirmed SARV-CoV-2 infection (cases) were enrolled, and each was paired with one control to give a total number of 2694 participants from 81 tertiary care centers. Among the women with SARS-CoV-2 infection, more cases were produced of perinatal mortality, overall maternal morbidity, COVID-19 maternal morbidity, C-sections, hypertensive maternal morbidity, and perinatal morbidity. Our results described an inverse association between HDI and maternofetal morbidity and mortality. Moreover, the countries with an HDI lower than 1 showed higher rates of patients with maternal COVID-19-related morbidity (6.0% vs. 2.4%, p < 0.001), a need for oxygen therapy (4.7% vs. 1.8%, p < 0.001), and maternal ICU admission (2.6% vs. 1.0%, p = 0.007). Compared to other risk factors such as overweight, obesity, preexisting and obstetric comorbidities, HDI emerged as an independent risk factor explaining much of the increased maternal–perinatal morbidity and mortality detected in our group of cases. Further research is needed to establish to confirm the real impact of this factor and its components on pregnancy outcomes.
PB MDPI
SN 2077-0383
YR 2021
FD 2021-08-17
LK https://hdl.handle.net/20.500.14352/5043
UL https://hdl.handle.net/20.500.14352/5043
LA eng
NO Cuñarro-López Y, Larroca SG-T, Pintado-Recarte P, Hernández-Martín C, Prats-Rodríguez P, Cano-Valderrama Ó, et al. Influence of the Human Development Index on the Maternal–Perinatal Morbidity and Mortality of Pregnant Women with SARS-CoV-2 Infection: Importance for Personalized Medical Care. JCM 2021;10:3631. https://doi.org/10.3390/jcm10163631.
NO This study (FIS-PI18/00912) was supported by the Instituto de Salud Carlos III (Plan Estatal de I + D + i 2013–2016) and cofinanced by the European Development Regional Fund ‘‘A way to achieve Europe’’ (ERDF) and B2017/BMD-3804 MITIC-CM.
NO Unión Europea
NO Comunidad de Madrid
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 30 sept 2024