RT Journal Article
T1 Vancomycin tolerance in Gram-positive cocci
A1 Moscoso, Miriam
A1 Domenech Lucas, Miriam
A1 García, Ernesto
AB Vancomycin, a glycopeptide antimicrobial agent, represents the last line of defence against a wide range of multi-resistant Gram-positive pathogens such as enterococci, staphylococci and streptococci. However, vancomycin-resistant enterococci and staphylococci, along with vancomycin-tolerant clinical isolates, are compromising the therapeutic efficacy of vancomycin. It is conceivable that tolerance may emerge during prolonged vancomycin use. It has not been until recently, however, that the molecular basis of this tolerance began to be understood. Superoxide anions might be involved in the bactericidal activity of vancomycin in enterococci, and recent evidence suggests that the stringent response is partly responsible for vancomycin tolerance in Enterococcus faecalis. The mechanism of vancomycin tolerance in Staphylococcus aureus and Streptococcus pneumoniae is sometimes associated with a reduction of autolysin activity. Vancomycin tolerance in S. aureus and S. pneumoniae also appears to be somehow related with the two-component regulatory systems linked to cell envelope stress, although the precise molecular regulatory pathways remain poorly defined.
PB Wiley
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/98239
UL https://hdl.handle.net/20.500.14352/98239
LA eng
NO Moscoso, Miriam, et al. «Vancomycin Tolerance in Gram-Positive Cocci: Vancomycin Tolerance». Environmental Microbiology Reports, vol. 3, n.o 6, diciembre de 2011, pp. 640-50. https://doi.org/10.1111/j.1758-2229.2011.00254.x.
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 25 dic 2025