RT Journal Article
T1 Prognostic value of corpus callosum injuries in severe head trauma
A1 Cicuendez, Marta
A1 Castaño León, Ana
A1 Ramos González, Ana
A1 Hilario Barrio, Amaya
A1 Gómez López, Pedro Antonio
A1 Lagares Gómez-Abascal, Alfonso
AB Background: This study was performed to investigate the relationship between corpus callosum (CC) injury and prognosis in traumatic axonal injury (TAI).Method: We retrospectively reviewed 264 patients with severe head trauma who underwent a conventional MR imaging in the first 60 days after injury. They were selected from a prospectively collected database of 1048 patients with severe head trauma admitted in our hospital. TAI lesions were defined as areas of increased signal intensity on T2 and FLAIR or areas of decreased signal on gradient-echo T2. We attempted to determine whether any MR imaging findings of TAI lesions at CC could be related to prognosis. Neurological impairment was assessed at 1 year after injury by means of GOS-E (good outcome being GOS-E 4/5 and bad outcome being GOS-E <4). We adjusted the multivariable analysis for the prognostic factors according to the IMPACT studies: the Core model (age, motor score at admission, and pupillary reactivity) and the Extended model (including CT information and second insults).Results: We found 97 patients (37 %) with TAI at CC and 167 patients (63 %) without CC lesions at MR. A total of 62 % of the patients with CC lesions had poor outcome, whereas 38 % showed good prognosis. The presence of TAI lesions at the corpus callosum was associated with poor outcome 1 year after brain trauma (p < 0.001, OR 3.8, 95 % CI: 2.04-7.06). The volume of CC lesions measured on T2 and FLAIR sequences was negatively correlated with the GOS-E after adjustment for independent prognostic factors (p = 0.01, OR 2.23, 95 % CI:1.17-4.26). Also the presence of lesions at splenium was statistically related to worse prognosis (p = 0.002, OR 8.1, 95 % CI: 2.2-29.82). We did not find statistical significance in outcome between hemorrhagic and non-hemorrhagic CC lesions.
PB The European Journal of Neurosurgery
SN 0001-6268
YR 2017
FD 2017-01
LK https://hdl.handle.net/20.500.14352/115554
UL https://hdl.handle.net/20.500.14352/115554
LA eng
NO Cicuendez M, Castaño-León A, Ramos A, Hilario A, Gómez PA, Lagares A. Prognostic value of corpus callosum injuries in severe head trauma. Acta Neurochir (Wien). 2017 Jan;159(1):25-32. doi: 10.1007/s00701-016-3000-4. Epub 2016 Oct 31. PMID: 27796652.
NO Instituto de Salud Carlos III
NO Unión Europea
DS Docta Complutense
RD 9 abr 2025