%0 Journal Article
%A Morón Nozaleda, María Goretti
%A Díaz Caneja, Covadonga M.
%A Rodríguez Toscano, Elisa
%A Arango López, Celso
%A Castro Fornieles, Josefina
%A De la Serna, Elena
%A Espliego, Ana
%A Sanchez Gistau, Vaness
%A Romero, Soledad
%A Baeza, Inmaculada
%A Sugranyes, Gisela
%A Moreno Ruiz, María del Carmen
%A Moreno Pardillo, Dolores María
%T A developmental approach to dimensional expression of psychopathology in child and adolescent offspring of parents with bipolar disorder
%D 2017
%@ 1018-8827
%U https://hdl.handle.net/20.500.14352/113021
%X Abstract The aim of this is to describe psychopathology,functioning and symptom dimensions accounting for subthresholdmanifestations and developmental status in childand adolescent offspring of parents with bipolar disorder(“high-risk offspring”). The study population comprised90 high-risk offspring (HR-offspring) and 107 offspring ofcommunity control parents (CC-offspring). Direct clinicalobservations and parental and offspring reports basedon selected standardized clinical scales were used to assessoffspring threshold and subthreshold diagnoses, symptomsand functioning. All outcomes were compared between the whole HR-offspring and CC-offspring samples and then bydevelopmental status. After controlling for potential confounders,HR-offspring showed significantly poorer adjustmentfor childhood (r = 0.18, p = 0.014) and adolescence(r = 0.21, p = 0.048) than CC-offspring, as well as moreemotional problems (r = 0.24, p = 0.001) and higherdepression scores (r = 0.16, p = 0.021). As for differencesin lifetime categorical diagnoses (threshold and subthreshold)between HR-offspring and CC-offspring, the prevalenceof disruptive disorders was higher in pre-pubertal HR-offspring(OR 12.78 [1.45–112.42]), while prevalence of mooddisorders was higher in post-pubertal HR-offspring (OR3.39 [1.14–10.06]). Post-pubertal HR-offspring presentedmore prodromal (r = 0.40, p = 0.001), negative (r = 0.38,p = 0.002), manic (r = 0.22, p = 0.035) and depressive(r = 0.23, p = 0.015) symptoms than pre-pubertal HR-offspring,as well as more peer relationship problems (r = 0.31,p = 0.004), poorer childhood adjustment (r = 0.22,p = 0.044) and worse current psychosocial functioning(r = 0.27, p = 0.04). Externalizing psychopathology is moreprevalent in pre-pubertal HR-offspring, while depressive andprodromal symptoms leading to functional impairment aremore prominent in post-pubertal HR-offspring. Developmentalapproaches and dimensional measures may be usefulfor identifying children at high risk of developing bipolardisorder and help guide specific preventive strategies.
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