RT Journal Article
T1 A developmental approach to dimensional expression of psychopathology in child and adolescent offspring of parents with bipolar disorder
A1 Morón Nozaleda, María Goretti
A1 Díaz Caneja, Covadonga M.
A1 Rodríguez Toscano, Elisa
A1 Arango López, Celso
A1 Castro Fornieles, Josefina
A1 De la Serna, Elena
A1 Espliego, Ana
A1 Sanchez Gistau, Vaness
A1 Romero, Soledad
A1 Baeza, Inmaculada
A1 Sugranyes, Gisela
A1 Moreno Ruiz, María del Carmen
A1 Moreno Pardillo, Dolores María
AB Abstract The aim of this is to describe psychopathology,functioning and symptom dimensions accounting for subthresholdmanifestations and developmental status in childand adolescent offspring of parents with bipolar disorder(“high-risk offspring”). The study population comprised90 high-risk offspring (HR-offspring) and 107 offspring ofcommunity control parents (CC-offspring). Direct clinicalobservations and parental and offspring reports basedon selected standardized clinical scales were used to assessoffspring threshold and subthreshold diagnoses, symptomsand functioning. All outcomes were compared between the whole HR-offspring and CC-offspring samples and then bydevelopmental status. After controlling for potential confounders,HR-offspring showed significantly poorer adjustmentfor childhood (r = 0.18, p = 0.014) and adolescence(r = 0.21, p = 0.048) than CC-offspring, as well as moreemotional problems (r = 0.24, p = 0.001) and higherdepression scores (r = 0.16, p = 0.021). As for differencesin lifetime categorical diagnoses (threshold and subthreshold)between HR-offspring and CC-offspring, the prevalenceof disruptive disorders was higher in pre-pubertal HR-offspring(OR 12.78 [1.45–112.42]), while prevalence of mooddisorders was higher in post-pubertal HR-offspring (OR3.39 [1.14–10.06]). Post-pubertal HR-offspring presentedmore prodromal (r = 0.40, p = 0.001), negative (r = 0.38,p = 0.002), manic (r = 0.22, p = 0.035) and depressive(r = 0.23, p = 0.015) symptoms than pre-pubertal HR-offspring,as well as more peer relationship problems (r = 0.31,p = 0.004), poorer childhood adjustment (r = 0.22,p = 0.044) and worse current psychosocial functioning(r = 0.27, p = 0.04). Externalizing psychopathology is moreprevalent in pre-pubertal HR-offspring, while depressive andprodromal symptoms leading to functional impairment aremore prominent in post-pubertal HR-offspring. Developmentalapproaches and dimensional measures may be usefulfor identifying children at high risk of developing bipolardisorder and help guide specific preventive strategies.
SN 1018-8827
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/113021
UL https://hdl.handle.net/20.500.14352/113021
LA eng
NO Morón-Nozaleda, M.G., Díaz Caneja, C.M., Rodríguez Toscano, E. et al. A developmental approach to dimensional expression of psychopathology in child and adolescent offspring of parents with bipolar disorder. Eur Child Adolesc Psychiatry 26, 1165–1175 (2017).
DS Docta Complutense
RD 11 abr 2025