RT Journal Article
T1 Heating at the Nanoscale through Drug-Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles
A1 Guisasola, Eduardo
A1 Baeza, Alejandro
A1 Asin, Laura
A1 De la Fuente, J. M.
A1 Vallet Regí, María Dulce Nombre
AB Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the us of responsive nanomaterials are not different, and researchers have carried out many attempts to overcome their drawbacks due to the valuable potential of these techniques. Here, an overview is presented of nanodevices based on magnetic- and photoresponsive nanocrystals that respond to magnetic fields and/or near-infrared stimuli for cancer therapies. Special attention is given to the synergic effect that can be achieved with nanoscale heating in combination with chemotherapy through drug-delivery devices to effectively kill cancer cells. In this way, the nanoparticles act as heating sources or “hot spots,” which can trigger cellular responses in the absence of a global temperature rise, making the tumor cells more sensitive to chemotherapeutics. The fabrication of optical and magnetic drug-delivery devices, the heating mechanisms, and their applications in tumor treatment are also summarized.
PB Wiley-Blackwell
SN 2366-9608
YR 2018
FD 2018-05-07
LK https://hdl.handle.net/20.500.14352/12071
UL https://hdl.handle.net/20.500.14352/12071
LA eng
NO RESEARCHER ID E-8300-2012 (Eduardo Guisasola Cal)ORCID 0000-0002-2549-1745 (Eduardo Guisasola Cal)RESEARCHER ID K-8193-2014 (Alejandro Baeza)ORCID 0000-0002-9042-8865 (Alejandro Baeza)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 4 may 2024