RT Journal Article
T1 Long‐Term Exposure to Isoflavones Alters the Hormonal Steroid Homeostasis‐Impairing Reproductive Function in Adult Male Wistar Rats
A1 Cáceres Ramos, Sara Cristina
A1 Crespo, Belen
A1 Alonso Diez, Angela
A1 Andrés Gamazo, Paloma Jimena De
A1 Millán Pastor, María Pilar
A1 Silván Granado, Gema
A1 Illera Del Portal, Josefina María
A1 Illera Del Portal, Juan Carlos
AB The consumption of isoflavones is gaining popularity worldwide due to their beneficial effects on health. However, isoflavones are considered to be endocrine disruptors and cause deleterious effects on hormone‐sensitive organs, especially in males. Therefore, this study aimed to deter‐mine if a continuous and prolonged exposure to isoflavones in adult males altered the endocrine axis effect of testicular function. For this purpose, seventy‐five adult male rats were administered with low and high mixtures of isoflavones (genistein and daidzein) for 5 months. The determinationof steroid hormones (progesterone, androstenedione, dehydroepiandrosterone, testosterone, dihydrotestosterone, 17β‐estradiol, and estrone sulphate) was carried out in serum and testicular homogenate samples. Sperm quality parameters and testicular histology were also determined. The results revealed that low and high doses of isoflavones promote a hormonal imbalance in androgen and estrogen production, resulting in a decrease in circulating and testicular androgen levels andan increase in estrogen levels. These results are associated with a reduction in the sperm quality parameters and a reduction in the testicular weight, both in the diameter of the seminiferous tubules and the height of the germinal epithelium. Altogether, these results suggest that a continuous ex‐posure to isoflavones in adult male rats causes a hormonal imbalance in the testes that disrupts the endocrine axis, causing defects in testicular function.
PB MDPI
SN 2072-6643
YR 2023
FD 2023-03-02
LK https://hdl.handle.net/20.500.14352/96852
UL https://hdl.handle.net/20.500.14352/96852
LA eng
NO Caceres, S.; Crespo, B.; Alonso‐Diez, A.; de Andrés, P.J.; Millan, P.; Silván, G.; Illera, M.J.; Illera, J.C. Long‐Term Exposure to Isoflavones Alter Hormonal Steroid Homeostasis Impairing Reproductive Function in Adult Male Wistar Rats. Nutrients 2023, 15, 1261.
DS Docta Complutense
RD 27 jul 2024