RT Journal Article
T1 Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
A1 Pashootan, Parya
A1 Saadati, Fatemeh
A1 Fahimi, Hossein
A1 Rahmati, Marveh
A1 Strippoli, Raffaele
A1 Zarrabi, Ali
A1 Cordani, Marco
A1 Moosavi, Mohammad Amin
AB Photodynamic therapy (PDT) represents a non-invasive treatment strategy currently utilized in the clinical management of selected cancers and infections. This technique is predicated on the administration of a photosensitizer (PS) and subsequent irradiation with light of specific wavelengths, thereby generating reactive oxygen species (ROS) within targeted cells. The cellular effects of PDT are dependent on both the localization of the PS and the severity of ROS challenge, potentially leading to the stimulation of various cell death modalities. For many years, the concept of regulated cell death (RCD) triggered by photodynamic reactions predominantly encompassed apoptosis, necrosis, and autophagy. However, in recent decades, further explorations have unveiled additional cell death modalities, such as necroptosis, ferroptosis, cuproptosis, pyroptosis, parthanatos, and immunogenic cell death (ICD), which helps to achieve tumor cell elimination. Recently, nanoparticles (NPs) have demonstrated substantial advantages over traditional PSs and become important components of PDT, due to their improved physicochemical properties, such as enhanced solubility and superior specificity for targeted cells. This review aims to summarize recent advancements in the applications of different metal-based NPs as PSs or delivery systems for optimized PDT in cancer treatment. Furthermore, it mechanistically highlights the contribution of RCD pathways during PDT with metal NPs and how these forms of cell death can improve specific PDT regimens in cancer therapy.
PB Elsevier
SN 0378-5173
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/92909
UL https://hdl.handle.net/20.500.14352/92909
LA eng
NO Pashootan, Parya, et al. «Metal-Based Nanoparticles in Cancer Therapy: Exploring Photodynamic Therapy and Its Interplay with Regulated Cell Death Pathways». International Journal of Pharmaceutics, vol. 649, enero de 2024, p. 123622. https://doi.org/10.1016/j.ijpharm.2023.123622.
NO National Institute of Genetic Engineering and Biotechnology (Iran)
NO Ministerio de Ciencia e Innovación (España)
NO European Commission
NO Ministry for Health of Italy
DS Docta Complutense
RD 21 abr 2025