RT Journal Article
T1 A multi-omics approach for understanding the effects of moderate wine consumption on human intestinal health
A1 Belda Aguilar, Ignacio
A1 Cueva, Carolina
A1 Tamargo, Alba
A1 Ravarani, Charles
A1 Acedo, Alberto
A1 Bartolomé Villar, Begoña
A1 Moreno-Arribas, M. Victoria
AB The human gut is a highly diverse microbial ecosystem. Although showing a well-defined core of dominant taxa, an interindividual variability exists in microbiome arrangement patterns, and the presence and proportion of specific species, determining individual metabolic features-metabotypes-which govern the health effects of dietary interventions (i.e. polyphenol consumption). Starting with a 19-volunteer human intervention study, divided into low, medium, and high wine-polyphenol-metabolizers, we detected interindividual discrepancies on the effect of wine consumption in gut bacterial alpha-diversity, but a significant homogenization of beta-diversity among moderate wine consumers, independently of their metabotype. In addition, the abundance of key health-related taxa such as Akkermansia sp. increased after moderate wine intake in the group of high polyphenol-metabolizers. Regarding the metabolic activity, significant (p < 0.05) positive correlations in the production of SCFAs were observed after wine intake. Finally, we were able to correlate the microbiome and the metabolome of the three metabotypes, and to identify some metabolites-biomarker species, highlighting the genera Phascolarctobacterium, Pelotomaculum and Prevotella, as positively correlated with polyphenol concentration, and Prevotella, Zymophilus and Eubacterium as positively correlated with SCFAs concentration in faeces. Our results contribute to the evidence of the need of including the microbiome variable in personalized nutrition programs, as different metabotyes respond differently to dietary interventions.
PB Royal Society of Chemistry
SN 2042-650X
YR 2021
FD 2021-04-16
LK https://hdl.handle.net/20.500.14352/8683
UL https://hdl.handle.net/20.500.14352/8683
LA eng
NO Ministerio de Ciencia, Innovación y Universidades (MICINN)
NO Comunidad de Madrid
NO Universidad Rey Juan Carlos / CSIC.
DS Docta Complutense
RD 9 abr 2025