RT Journal Article
T1 Tenofovir Disoproxil Fumarate Reduces the Severity of COVID‐19 in Patients with Chronic Hepatitis B
A1 Mateos‐Muñoz, B
A1 Bañares Cañizares, Rafael
A1 Moreno Guillén, Santiago
A1 Albillos, A
AB Background and Aims HIV-positive patients on tenofovir hydroxyl fumarate (TDF)/emtricitabine have a lower risk of COVID-19 and hospitalization than those given other treatments. Our aim was to analyze the severity of COVID-19 in patients with chronic hepatitis B (CHB) on TDF or entecavir (ETV).Methods Spanish hospital databases (n = 28) including information regarding adult CHB patients on TDF or ETV for the period February 1st to November 30th 2020 were searched for COVID-19, defined as a positive SARS-CoV-2 polymerase chain reaction, and for severe COVID-19.Results Of 4736 patients, 117 had COVID-19 (2.5%), 67 on TDF and 50 on ETV. Compared to patients on TDF, those on ETV showed (p < 0.05) greater rates of obesity, diabetes, ischemic cardiopathy, and hypertension. COVID-19 incidence was similar in both groups (2.3 vs. 2.6%). Compared to TDF, patients on ETV more often (p < 0.01) had severe COVID-19 (36 vs. 6%), required intensive care unit (ICU) (10% vs. 0) or ventilatory support (20 vs. 3%), were hospitalized for longer (10.8 ± 19 vs. 3.1 ± 7 days) or died (10 vs. 1.5%, p = 0.08). In an IPTW propensity score analysis adjusted for age, sex, obesity, comorbidities, and fibrosis stage, TDF was associated with a sixfold reduction in severe COVID-19 risk (adjusted-IPTW-OR 0.17, 95%CI 0.04–0.67, p = 0.01).Conclusion Compared to ETV, TDF seems to play a protective role in CHB patients with SARS-CoV-2 whereby the risk of severe COVID-19 is lowered.
PB Springer Nature Link
YR 2023
FD 2023-02-03
LK https://hdl.handle.net/20.500.14352/126400
UL https://hdl.handle.net/20.500.14352/126400
LA eng
NO Beatriz Mateos‐Muñoz, María Buti, Inmaculada Fernández Vázquez, Marta Hernández Conde,  Vanesa Bernal‐Monterde, Fernando Díaz‐Fontenla, Rosa María Morillas,  Luisa García‐Buey, Ester Badía, Mireia Miquel, Alberto Amador‐Navarrete, Sergio Rodríguez‐Taje, Lucía Ramos‐Merino, Antonio Madejón, Montserrat García‑Retortillo, Juan Ignacio Arenas, Joaquín Cabezas Jesús Manuel González Santiago, Conrado Fernández‑Rodríguez, Patricia Cordero,  Moisés Diago, Antonio Mancebo, Alberto Pardo, Manuel Rodríguez, Elena Hoyas, Jose Javier Moreno, . Juan Turnes, Miguel Ángel Simón, Cristina Marcos‑Fosch,  José Luis Calleja, Rafael Bañares,  Sabela Lens, Javier Garcia‑Samaniego, Javier Crespo, Manuel Romero‑Gomez, Francisco Gea,  Enrique Rodríguez de Santiago1, Santiago Moreno, Agustin Albillos.Tenofovir Disoproxil Fumarate Reduces the Severity of COVID‐19 in Patients with Chronic Hepatitis B. Dig Dis Sci, 2023: 68:2731-2737.
DS Docta Complutense
RD 9 abr 2026