RT Journal Article
T1 Cognitive Alterations in Addictive Disorders: A Translational Approach
A1 Gasparyan, Ani
A1 Maldonado Sánchez, Daniel
A1 Navarrete, Francisco
A1 Sion, Ana Mª Alexandra
A1 Navarro, Daniela
A1 García Gutiérrez, María Salud
A1 Rubio Valladolid, Gabriel
A1 Jurado Barba, Rosa
A1 Manzanares, Jorge
AB The cognitive decline in people with substance use disorders is well known and can be found during both the dependence and drug abstinence phases. At the clinical level, cognitive decline impairs the response to addiction treatment and increases dropout rates. It can be irreversible, even after the end of drug abuse consumption. Improving our understanding of the molecular and cellular alterations associated with cognitive decline could be essential to developing specific therapeutic strategies for its treatment. Developing animal models to simulate drug abuse-induced learning and memory alterations is critical to continue exploring this clinical situation. The main aim of this review is to summarize the most recent evidence on cognitive impairment and the associated biological markers in patients addicted to some of the most consumed drugs of abuse and in animal models simulating this clinical situation. The available information suggests the need to develop more studies to further explore the molecular alterations associated with cognitive impairment, with the ultimate goal of developing new potential therapeutic strategies.
PB MDPI
SN 2227-9059
YR 2023
FD 2023-06-23
LK https://hdl.handle.net/20.500.14352/110673
UL https://hdl.handle.net/20.500.14352/110673
LA eng
NO Gasparyan, A.; Maldonado Sanchez, D.; Navarrete, F.; Sion, A.; Navarro, D.; García-Gutiérrez, M.S.; Rubio Valladolid, G.; Jurado Barba, R.; Manzanares, J. Cognitive Alterations in Addictive Disorders: A Translational Approach. Biomedicines 2023, 11, 1796. https://doi.org/10.3390/biomedicines11071796
NO 2023 Descuento MDPI
NO Instituto de Salud Carlos III
NO Ministerio de Sanidad (España)
DS Docta Complutense
RD 10 abr 2025