RT Journal Article
T1 Guiding Clinical Prescription of Topical Extemporaneous Formulations of Sodium Cromoglycate Based on Pharmaceutical Performance
A1 González González, Olga
A1 Leal, Enrique
A1 Martín Martínez, Mercedes
A1 Bautista Chávez, Liliana
A1 Ballesteros Papantonakis, María De La Paloma
A1 Torrado Durán, Juan José
A1 Serrano López, Dolores Remedios
AB Cromoglycate (SCG) is widely used for allergy processes, and inflammatory states acting as a mast cell membrane stabilizer that inhibits the histamine and mediator release. Currently, SCG topical extemporaneous compounding formulations are prepared in hospitals and community pharmacies, as no industrial fabricated medicines are available in Spain. The stability of these formulations is unknown. Additionally, there are no clear guidelines on which concentration and vehicle are more suitable to enhance permeation across the skin. In this work, the stability of commonly prescribed topical SCG formulations in clinical practice was evaluated. Different vehicles commonly employed by pharmacists daily for formulating topical SCG were investigated (Eucerinum, Acofar Creamgel, and Beeler’s base) at different concentrations, ranging from 0.2 to 2%. The stability of topical extemporaneous compounded SCG formulations can be extended for up to three months at room temperature (25 °C). Creamgel 2% formulations significantly improved the topical permeation of SCG across the skin, being 4.5-fold higher than formulations prepared with Beeler’s base. The reason attributed to this performance can be related to the lower droplet size formed upon dilution in aqueous media combined with a lower viscosity, which facilitates its application and extensibility on the skin. The higher the SCG concentration in Creamgel formulations, the higher the permeability across both synthetic membranes and pig skin (p-value < 0.05). These preliminary results can be used as a guide to prompt a rational prescription of topical SCG formulations.
PB MDPI
SN 1999-4923
YR 2023
FD 2023-05-29
LK https://hdl.handle.net/20.500.14352/111908
UL https://hdl.handle.net/20.500.14352/111908
LA eng
NO González-González, O.; Leal, E.; Martín-Martínez, M.; Bautista, L.; Ballesteros, M.P.; Torrado, J.J.; Serrano, D.R. Guiding Clinical Prescription of Topical Extemporaneous Formulations of Sodium Cromoglycate Based on Pharmaceutical Performance. Pharmaceutics 2023, 15, 1609. https://doi.org/10.3390/pharmaceutics15061609
NO 2023 Descuento MDPI
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 6 abr 2025