%0 Journal Article
%A Sánchez Tena, Miguel Ángel
%A Torralbo Jiménez, Pilar 
%A Giron, Natalia 
%A De la Heras, Beatriz
%A Herrero Vanrell, María Del Rocío
%A Arriola Villalobos, Pedro
%A Díaz Valle, David
%A Álvarez Barrientos, Alberto 
%A Benítez Del Castillo Sánchez, José Manuel
%T Comparative Analysis of Carmellose 0.5% Versus Hyaluronate 0.15% in Dry Eye: A Flow Cytometric Study
%D 2010
%@ 0277-3740
%U https://hdl.handle.net/20.500.14352/94626
%X Purpose: To compare the effects of Viscofresh 0.5% (carmellose sodium 0. 5%) versus Lubristil (sodium hyaluronate 0.15%) in dry eye syndrome and to study the influence of these two treatments on the expression of various inflammatory markers by flow cytometry in impression cytology specimens.Methods: In this randomized, masked-observer, parallel group, single-center study, 15 patients with dry eye syndrome were randomized to sodium carmellose 0.5% or sodium hyaluronate 0.15% 1-month treatment after a 1-week washout period. Corneal staining with flurescein, breakup time, Schirmer 1 test with anesthesia (Jones test), and tear clearance were assessed. Besides, conjunctival impression cytology was performed to investigate inflammatory markers (CD3, CD11b, and HLA-DR) using flow cytometry.Results: Carmellose group shows statistical improvement compared with the hyaluronate group in breakup time, corneal staining, and HLA-DR. The two other inflammatory markers had also a tendency for a decreased expression in both groups, with no statistical significance. There were neither visual acuity loss nor other complications related to treatment.Conclusion: Both artificial tears improve dry eye signs and symptoms and inflammatory markers expression, with significant better results in carmellose group.
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