TY - JOUR AU - Martín De Saavedra Álvarez De Uribarri, María Dolores AU - Navarro, Elisa AU - Moreno‐Ortega, Ana J. AU - Cunha,, Mauricio P. AU - Buendia, Izaskun AU - Hernansanz‐Agustín, Pablo AU - León Martínez, Rafael AU - Cano‐Abad,, María F. AU - Martínez‐Ruiz, Antonio AU - Martínez‐Murillo, Ricardo AU - Duchen, Michael R. AU - López, Manuela G. PY - 2018 DO - 10.1111/jnc.14293 SN - 0022-3042 UR - https://hdl.handle.net/20.500.14352/93444 T2 - Journal of Neurochemistry AB - Growing evidence suggests a close relationship between Alzheimer′s Disease (AD) and cerebral hypoxia. Astrocytes play a key role in brain homeostasis and disease states, while some of the earliest changes in AD occur in astrocytes. We have therefore... LA - eng M2 - 170 PB - Wiley KW - Alzheimer´s disease KW - astrocytes KW - calcium dyshomeostasis KW - cell death KW - ischemia KW - mitochondrial dysfunction TI - The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation, and mitochondrial abnormalities TY - journal article VL - 145 ER -