RT Journal Article
T1 Pulmonary surfactant metabolism in the alveolar airspace: Biogenesis,extracellular conversions, recycling
A1 Olmeda Lozano, Bárbara
A1 Martínez Calle, Marta
A1 Pérez-Gil, Jesús
AB Pulmonary surfactant is a lipid–protein complex that lines and stabilizes the respiratory interface in the alveoli, allowing for gas exchange during the breathing cycle. At the same time, surfactant constitutes the first line of lung defense against pathogens. This review presents an updated view on the processes involved in biogenesis and intracellular processing of newly synthesized and recycled surfactant components, as well as on the extracellular surfactant transformations before and after the formation ofthe surface active film atthe air–water interface. Special attention is paid to the crucial regulation of surfactant homeostasis, because its disruption is associated with several lung pathologies.
PB Elsevier
SN 0940-9602, ESSN: 1618-0402
YR 2017
FD 2017-01
LK https://hdl.handle.net/20.500.14352/18064
UL https://hdl.handle.net/20.500.14352/18064
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
DS Docta Complutense
RD 6 abr 2025