RT Journal Article
T1 Cadmium alters heat shock protein pathways in SN56 cholinergic neurons, leading to AB and phosphorylated Tau protein generation and cell death
A1 Moyano-Cires Ivanoff, Paula Viviana
A1 García Sánchez, José Manuel
A1 Lobo Alonso, Margarita
A1 Anadón Baselga, María José
A1 Sola Vendrell, Emma
A1 Pelayo Alarcón, Adela
A1 García Lobo, Jimena
A1 Frejo Moya, María Teresa
A1 Pino Sans, Javier Del
AB Cadmium, a neurotoxic environmental compound, produces cognitive disorders, although the mechanism remains unknown. Cadmium induces a more pronounced cell death on cholinergic neurons from basal forebrain (BF), mediated, in part, by increase in Aβ and total and phosphorylated Tau protein levels, which may explain cadmium effects on learning and memory processes. Cadmium downregulates the expression of heat shock proteins (HSPs) HSP 90, HSP70 and HSP27, and of HSF1, the master regulator of the HSP pathway. HSPs proteins reduce the production of Aβ and phosphorylated Tau proteins and avoid cell death pathways induction. Thus, we hypothesized that cadmium induced the production of Aβ and Tau proteins by HSP pathway disruption through HSF1 expression alteration, leading to BF cholinergic neurons cell death. Our results show that cadmium downregulates HSF1, leading to HSP90, HSP70 and HSP27 gene expression downregulation in BF SN56 cholinergic neurons. In addition, cadmium induced Aβ and total and phosphorylated Tau proteins generation, mediated partially by HSP90, HSP70 and HSP27 disruption, leading to cell death. These results provide new understanding of the mechanisms contributing to cadmium harmful effects on cholinergic neurons.
PB Elsevier
SN 0278-6915
YR 2018
FD 2018-09-11
LK https://hdl.handle.net/20.500.14352/100512
UL https://hdl.handle.net/20.500.14352/100512
LA eng
NO Cadmium alters heat shock protein pathways in SN56 cholinergic neurons, leading to AB and phosphorylated Tau protein generation and cell death.  Paula Moyano, Jose Manuel García, Margarita Lobo, María José Anadon, Emma Sola, Adela Pelayo, Jimena García, Maria Teresa Frejo, Javier del Pino. Food and Chemical Toxicology 121 (2018): 297-308
NO Banco Santander
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 29 sept 2024