RT Journal Article
T1 Insulin resistance modulates iron-related proteins in adipose tissue
A1 Moreno Navarrete, José María
A1 Garrido Novelle, Marta
A1 Catalán, Victoria
A1 Ortega Gómez, Francisco
A1 Moreno, María
A1 Gómez Ambrosi, Javier
A1 Xifra, Gemma
A1 Serrano, Marta
A1 Guerra, Ester
A1 Ricart, Wilfredo
A1 Frühbeck, Gema
A1 Diéguez, Carlos
A1 Fernández Real, José Manuel
AB OBJECTIVECirculating markers of iron overload are associated with insulin resistance. Less is known about the impact of iron overload on adipose tissue (AT). We hypothesized that gene expression markers of iron metabolism in AT could be associated with insulin action.RESEARCH DESIGN AND METHODSThe AT expression of ferroportin (SLC40A1), transferrin (TF), TF receptor (TFRC), ferritin (FT) heavy polypeptide 1 (FTH1), and FT light polypeptide (FTL) was analyzed cross-sectionally in three independent cohorts and also after weight loss–induced changes in insulin sensitivity (clamp M value) in an independent fourth cohort.RESULTSIn human AT, TF mRNA and protein levels were decreased with obesity and insulin resistance in the three cohorts and were positively associated with adipogenic mRNAs and insulin action. Otherwise, FTL mRNA and protein and SLC40A1 transcripts were positively associated with BMI and negatively linked to adipogenic genes and insulin action. Bariatric surgery–induced weight loss led to increased TF and decreased TFRC, FTH1, FTL, and SLC40A1 in subcutaneous AT in parallel to improved insulin action.CONCLUSIONSThese results suggest that iron overload impacts on AT in association with insulin resistance.
PB American Diabetes Association
SN 0149-5992
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/94877
UL https://hdl.handle.net/20.500.14352/94877
LA eng
NO José María Moreno-Navarrete, Marta G. Novelle, Victoria Catalán, Francisco Ortega, Maria Moreno, Javier Gomez-Ambrosi, Gemma Xifra, Marta Serrano, Ester Guerra, Wifredo Ricart, Gema Frühbeck, Carlos Diéguez, José Manuel Fernández-Real; Insulin Resistance Modulates Iron-Related Proteins in Adipose Tissue. Diabetes Care 1 April 2014; 37 (4): 1092–1100. https://doi.org/10.2337/dc13-1602
NO This work was partially supported by research grants FIS-PI11/00214, FIS-PI12/02631, and FIS-PI12/00515 from the Instituto de Salud Carlos III from Spain. CIBER de la Fisiopatología de la Obesidad y la Nutricion is an initiative from the Instituto de Salud Carlos III from Spain.
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 8 abr 2025