RT Journal Article
T1 Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach
A1 Montaño, Karen J.
A1 Cuéllar Del Hoyo, María Del Carmen
A1 Sotillo, Javier
A2 Cinzia Cantacessi, 
AB Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity. Due to the difficulty in studying STH human infections, rodent models have become increasingly used, mainly because of their similarities in life cycle. Ascaris suum and Trichuris muris have been proven appropriate and low maintenance models for the study of ascariasis and trichuriasis. In the case of hookworms, despite most of the murine models do not fully reproduce the life cycle of Necator americanus, their proteomic similarity makes them highly suitable for the development of novel vaccine candidates and for the study of hookworm biological features. Furthermore, these models have been helpful in elucidating some basic aspects of our immune system, and are currently being used by numerous researchers to develop novel molecules with immunomodulatory proteins. Herein we review the similarities in the proteomic composition between Nippostrongylus brasiliensis, Heligmosomoides polygyrus bakeri and Trichuris muris and their respective human counterpart with a focus on the vaccine candidates and immunomodulatory proteins being currently studied.
PB Frontiers
SN 2235-2988
YR 2021
FD 2021-04-22
LK https://hdl.handle.net/20.500.14352/101468
UL https://hdl.handle.net/20.500.14352/101468
LA eng
NO Montaño, Karen J., et al. «Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach». Frontiers in Cellular and Infection Microbiology, vol. 11, abril de 2021, p. 639573. DOI.org (Crossref), https://doi.org/10.3389/fcimb.2021.639573.
NO Miguel Servet Fellow
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 12 oct 2024