RT Journal Article
T1 Placebo effect in child and adolescent psychiatric trials
A1 Parellada, Mara
A1 Moreno Ruiz, María del Carmen
A1 Moreno Romo, Miguel Ángel
A1 Espliego, Ana
A1 Portugal Fernández De Rivero, Enrique De
A1 Arango López, Celso
AB Much literature has been written in the field of child psychiatry regarding the placebo as a tool to test drug efficacy in clinical trials, but quite little regarding the placebo effect itself or its clinical use in child psychiatry. In this article, we aim to critically review the literature regarding the placebo effect in children and adolescents with mental disorders, focusing especially on factors influencing the placebo effect and how they may influence the interpretation of clinical trials. The placebo effect seems to be more marked in children than adults, and particularly in children and adolescents with depression, although it is pervasive across ages and is present in non-psychiatric conditions as well. The use of a placebo in clinical trials as a comparator with drugs that have moderate efficacy at most makes it difficult to obtain positive results, and much effort is needed to design very high quality clinical trials that may overcome the limitations of using a placebo. In addition, the placebo effect across ages and clinical conditions must be tested directly (compared with no treatment whenever possible), in order to characterise which placebos work for what and to determine their use in clinical settings.
PB Elsevier
YR 2012
FD 2012-11-20
LK https://hdl.handle.net/20.500.14352/115192
UL https://hdl.handle.net/20.500.14352/115192
LA eng
NO Parellada M, Moreno C, Moreno M, Espliego A, de Portugal E, Arango C. Placebo effect in child and adolescent psychiatric trials. Eur Neuropsychopharmacol. 2012 Nov;22(11):787-99. doi: 10.1016/j.euroneuro.2011.09.007
DS Docta Complutense
RD 18 abr 2025