RT Journal Article
T1 New photocrosslinked 3D foamed scaffolds based on GelMA copolymers: potential application in bone tissue engineering
A1 Pablos Lagartos, Jesús Luis
A1 Jiménez Holguín, Javier
A1 Sánchez Salcedo, Sandra
A1 Salinas Sánchez, Antonio Jesús
A1 Corrales, Teresa
A1 Vallet Regí, María Dulce Nombre
A2 MDPI, 
AB The production of customized polymeric hydrogels in the form of 3D scaffolds with application in bone tissue engineering is currently a topic of great interest. Based on gelatin methacryloyl (GelMa) as one of the most popular used biomaterials, GelMa with two different methacryloylation degrees (DM) was obtained, to achieve crosslinked polymer networks by photoinitiated radical polymerization. In this work, we present the obtention of new 3D foamed scaffolds based on ternary copolymers of GelMa with vinylpyrrolidone (VP) and 2-hydroxyethylmethacrylate (HEMA). All biopolymers obtained in this work were characterized by infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), whose results confirm the presence of all copolymers in the crosslinked biomaterial. In addition, scanning electron microscopy (SEM) pictures were obtained verifying the presence of the porosity created by freeze-drying process. In addition, the variation in its swelling degree and its enzymatic degradation in vitro was analyzed as a function of the different copolymers obtained. This has allowed us to observe good control of the variation in these properties described above in a simple way by varying the composition of the different comonomers used. Finally, with these concepts in mind, biopolymers obtained were tested through assessment of several biological parameters such as cell viability and differentiation with MC3T3-E1 pre-osteoblastic cell line. Results obtained show that these biopolymers maintain good results in terms of cell viability and differentiation, along with tunable properties in terms of hydrophilic character, mechanical properties and enzymatic degradation. © 2023 by the authors.
PB MDPI
YR 2023
FD 2023-05-11
LK https://hdl.handle.net/20.500.14352/103690
UL https://hdl.handle.net/20.500.14352/103690
LA eng
NO Pablos, J.L.; Jiménez-Holguín, J.; Salcedo, S.S.; Salinas, A.J.; Corrales, T.; Vallet-Regí, M. New Photocrosslinked 3D Foamed Scaffolds Based on GelMA Copolymers: Potential Application in Bone Tissue Engineering. Gels 2023, 9, 403. https://doi.org/10.3390/gels9050403
NO 2023 Descuentos MDPI
NO Instituto de Salud Carlos III (España)
NO European Research Council
NO European Commission
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 22 jul 2024